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1

Peptide and protein drugs: The study of their metabolism and catabolism by mass spectrometry

Theodora Katsila, Alexandros P. Siskos, Constantin Tamvakopoulos

Journal:

Mass Spectrometry Reviews

Year:

2012

Language:

english

File:

PDF, 1.32 MB

english, 2012

2

Oral Administration of Chios Mastic Gum or Extracts in Mice: Quantification of Triterpenic Acids by Liquid Chromatography-Tandem Mass Spectrometry

Lemonakis, Nikolaos, Magiatis, Prokopios, Kostomitsopoulos, Nikolaos, Skaltsounis, Alexios-Leandros, Tamvakopoulos, Constantin

Journal:

Year:

2011

Language:

english

File:

PDF, 308 KB

english, 2011

3

Design and synthesis of novel 7-aminosubstituted pyrido[2,3-b]pyrazines exhibiting anti-breast cancer activity

Argyros, Orestis, Lougiakis, Nikolaos, Kouvari, Eva, Papafotika, Alexandra, Raptopoulou, Catherine P., Psycharis, Vassilis, Christoforidis, Savvas, Pouli, Nicole, Marakos, Panagiotis, Tamvakopoulos, C

Journal:

European Journal of Medicinal Chemistry

Year:

2017

Language:

english

File:

PDF, 1.32 MB

english, 2017

4

Determination of brain and plasma drug concentrations by liquid chromatography/tandem mass spectrometry

C. S. Tamvakopoulos, L. F. Colwell, K. Barakat, J. Fenyk-Melody, P. R. Griffin, R. Nargund, B. Palucki, I. Sebhat, X. Shen, R. A. Stearns

Journal:

Rapid Communications in Mass Spectrometry

Year:

2000

Language:

english

File:

PDF, 92 KB

english, 2000

5

Synthesis of ω-labelled fatty acids

C. S. Tamvakopoulos, V. E. Anderson

Journal:

Journal of Labelled Compounds and Radiopharmaceuticals

Year:

1990

Language:

english

File:

PDF, 183 KB

english, 1990

6

In vivo evaluation and in vitro metabolism of leuprolide in mice—mass spectrometry-based biomarker measurement for efficacy and toxicity

Zacharias D. Sofianos, Theodora Katsila, Nikolaos Kostomitsopoulos, Vaggelis Balafas, John Matsoukas, Theodoros Tselios, Constantin Tamvakopoulos

Journal:

Journal of Mass Spectrometry

Year:

2008

Language:

english

File:

PDF, 385 KB

english, 2008

7

Mass spectrometry for the quantification of bioactive peptides in biological fluids

Constantin Tamvakopoulos

Journal:

Mass Spectrometry Reviews

Year:

2007

Language:

english

File:

PDF, 360 KB

english, 2007

8

Detection of acyl-coenzyme a thioester intermediates of fatty acid β-oxidation as the N-acylglycines by negative-ion chemical ionization gas chromatography—Mass spectrometry

Constantine S. Tamvakopoulos, Vernon E. Anderson

Journal:

Analytical Biochemistry

Year:

1992

Language:

english

File:

PDF, 814 KB

english, 1992

9

Synthesis and SAR of potent and orally bioavailable tert-butylpyrrolidine archetype derived melanocortin subtype-4 receptor modulators

Liangqin Guo, Zhixiong Ye, Feroze Ujjainwalla, Heather L. Sings, Iyassu K. Sebhat, John Huber, David H. Weinberg, Rui Tang, Tanya MacNeil, Constantin Tamvakopoulos, Qianping Peng, Euan MacIntyre, Lex

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2008

Language:

english

File:

PDF, 163 KB

english, 2008

10

Rapid pharmacokinetic screening for the selection of new drug discovery candidates using a generic isocratic liquid chromatography–atmospheric pressure ionization tandem mass spectrometry method

Lawrence F. Colwell Jr., Constantin S. Tamvakopoulos, Pei Ran Wang, James V. Pivnichny, Thomas L. Shih

Journal:

Journal of Chromatography B

Year:

2002

Language:

english

File:

PDF, 200 KB

english, 2002

11

Analysis of betamethasone in rat plasma using automated solid-phase extraction coupled with liquid chromatography–tandem mass spectrometry. Determination of plasma concentrations in rat following oral and intravenous administration

C.S Tamvakopoulos, J.M Neugebauer, M Donnelly, P.R Griffin

Journal:

Journal of Chromatography B

Year:

2002

Language:

english

File:

PDF, 466 KB

english, 2002

12

A liquid chromatographic/tandem mass spectroscopic method for quantification of the cyclic peptide melanotan-II. Plasma and brain tissue concentrations following administration in mice

Sophia Hatziieremia, Nikolaos Kostomitsopoulos, Vagelis Balafas, Constantin Tamvakopoulos

Journal:

Rapid Communications in Mass Spectrometry

Year:

2007

Language:

english

File:

PDF, 177 KB

english, 2007

13

Determination of melanotan-II in rat plasma by liquid chromatography/tandem mass spectrometry: determination of pharmacokinetic parameters in rat following intravenous administration

S. Mock, X. Shen, C. Tamvakopoulos

Journal:

Rapid Communications in Mass Spectrometry

Year:

2002

Language:

english

File:

PDF, 138 KB

english, 2002

14

Analysis of thein vitrometabolites of diferuloylmethane (curcumin) by liquid chromatography — tandem mass spectrometry on a hybrid quadrupole linear ion trap system: newly identified metabolites

Constantin Tamvakopoulos, Zacharias D. Sofianos, Spiros D. Garbis, Panayotis Pantazis

Journal:

European Journal of Drug Metabolism and Pharmacokinetics

Year:

2007

Language:

english

File:

PDF, 737 KB

english, 2007

15

Scapholunate dissociation: an overview of the clinical entity and current treatment options

Steven Lau, Shyam Sundar Swarna, George S. Tamvakopoulos

Journal:

European Journal of Orthopaedic Surgery & Traumatology

Year:

2009

Language:

english

File:

PDF, 489 KB

english, 2009

16

Long-Chain Acyl-CoA Profiles in Cultured Fibroblasts from Patients with Defects in Fatty Acid Oxidation

C.S. Tamvakopoulos, S. Willi, V.E. Anderson, D.E. Hale

Journal:

Biochemical and Molecular Medicine

Year:

1995

File:

PDF, 595 KB

1995

17

Exploring the site of anorectic action of peripherally administered synthetic melanocortin peptide MT-II in rats

Prashant Trivedi, Michael Jiang, Constantin C Tamvakopoulos, Xiaolan Shen, Hong Yu, Steven Mock, Judy Fenyk-Melody, Lex H.T Van der Ploeg, Xiao-Ming Guan

Journal:

Year:

2003

Language:

english

File:

PDF, 667 KB

english, 2003

18

The clinical significance of theFUS-CREB3L2translocation in low-grade fibromyxoid sarcoma

Barry Rose, George S Tamvakopoulos, Kamaljit Dulay, Robin Pollock, John Skinner, Timothy Briggs, Steven Cannon

Journal:

Journal of Orthopaedic Surgery and Research

Year:

2011

Language:

english

File:

PDF, 840 KB

english, 2011

19

UP-02.42: Quantitative proteomic approaches for the determination of carcinogenesis biomarkers in prostate tissue

S. Tyritzis, G. Spiros, P. Zerefos, A. Papadopoulou, A. Vlahou, C. Tamvakopoulos, S. Kossida, J. Diaz, K. Pavlakis, C. Constantinides

Journal:

Year:

2006

Language:

english

File:

PDF, 73 KB

english, 2006

20

824 Cancer Cell's Surface Traits – an Ally in Designing Targeted Cancer Therapies – a GnRH Based Approach

T. Karampelas, O. Argyros, N. Kostomitsopoulos, K. Morgan, N. Sayyad, A.G. Tzakos, D. Fokas, C. Tamvakopoulos

Journal:

European Journal of Cancer

Year:

2012

Language:

english

File:

PDF, 51 KB

english, 2012

21

Metabolism and Anticancer Activity of the Curcumin Analogue, Dimethoxycurcumin

Tamvakopoulos, C., Dimas, K., Sofianos, Z. D., Hatziantoniou, S., Han, Z., Liu, Z.-L., Wyche, J. H., Pantazis, P.

Journal:

Clinical Cancer Research

Year:

2007

Language:

english

File:

PDF, 400 KB

english, 2007

22

A technique for functional liver autotransplantation: Observations on survival, function, and regeneration of the autotransplant

S.K. Tamvakopoulos, H.T. Randall, J.L. Van Lancker

Journal:

Journal of Surgical Research

Year:

1969

Language:

english

File:

PDF, 520 KB

english, 1969

23

Rationally designed cyclic analogues of luteinizing hormone-releasing hormone: Enhanced enzymatic stability and biological properties

Laimou, Despina, Katsila, Theodora, Matsoukas, John, Schally, Andrew, Gkountelias, Kostas, Liapakis, George, Tamvakopoulos, Constantin, Tselios, Theodore

Journal:

European Journal of Medicinal Chemistry

Year:

2012

Language:

english

File:

PDF, 544 KB

english, 2012

24

Evaluation of gonadotropin-releasing hormone analogues in mice – pharmacokinetic studies and biomarker based efficacy by mass spetrometry

T. Katsila, Z.D. Sofianos, E. Balafas, N. Kostomitsopoulos, J. Matsoukas, T. Tselios, C. Tamvakopoulos

Journal:

European Journal of Cancer Supplements

Year:

2008

Language:

english

File:

PDF, 97 KB

english, 2008

25

Search for Potential Markers for Prostate Cancer Diagnosis, Prognosis and Treatment in Clinical Tissue Specimens Using Amine-Specific Isobaric Tagging (iTRAQ) with Two-Dimensional Liquid Chromatography and Tandem Mass Spectrometry

Garbis, Spiros D., Tyritzis, Stavros I., Roumeliotis, Theodoros, Zerefos, Panagiotis, Giannopoulou, Eugenia G., Vlahou, Antonia, Kossida, Sophia, Diaz, Jose, Vourekas, Stavros, Tamvakopoulos, Constant

Journal:

Journal of Proteome Research

Year:

2008

Language:

english

File:

PDF, 5.67 MB

english, 2008

26

Simultaneous Absolute Quantification of the Glucose-Dependent Insulinotropic Polypeptides GIP 1−42 and GIP 3−42 in Mouse Plasma by LC/ESI-MS/MS: Preclinical Evaluation of DP-IV Inhibitors

Siskos, Alexandros P., Katsila, Theodora, Balafas, Evangelos, Kostomitsopoulos, Nikolaos, Tamvakopoulos, Constantin

Journal:

Journal of Proteome Research

Year:

2009

Language:

english

File:

PDF, 4.50 MB

english, 2009

27

Effects of X-Radiation on Amino Acid Incorporation into Regenerating Liver Proteins

K. Ariyama, N. Fausto, E. Tamvakopoulos and J. L. van Lancker

Journal:

Radiation Research

Year:

1970

Language:

english

File:

PDF, 946 KB

english, 1970

28

755: A gemcitabine prodrug for the treatment of castration-resistant prostate cancer: Reduced metabolic inactivation combined with targeted drug delivery

Karampelas, T., Argyros, O., Sayyad, N., Tzakos, A.G., Fokas, D., Tamvakopoulos, C.

Journal:

European Journal of Cancer

Year:

2014

Language:

english

File:

PDF, 63 KB

english, 2014

29

The Role of Dipeptidyl Peptidase IV in the Cleavage of Glucagon Family Peptides: IN VIVO METABOLISM OF PITUITARY ADENYLATE CYCLASE-ACTIVATING POLYPEPTIDE-(1-38)

Zhu, L., Tamvakopoulos, C., Xie, D., Dragovic, J., Shen, X., Fenyk-Melody, J. E., Schmidt, K., Bagchi, A., Griffin, P. R., Thornberry, N. A., Sinha Roy, R.

Journal:

Journal of Biological Chemistry

Year:

2003

Language:

english

File:

PDF, 683 KB

english, 2003

30

Therapeutic Effects of an Anti-Myc Drug on Mouse Pancreatic Cancer

Stellas, D., Szabolcs, M., Koul, S., Li, Z., Polyzos, A., Anagnostopoulos, C., Cournia, Z., Tamvakopoulos, C., Klinakis, A., Efstratiadis, A.

Journal:

JNCI Journal of the National Cancer Institute

Year:

2014

Language:

english

File:

PDF, 1.38 MB

english, 2014

31

Toll-like receptor 7 stimulates production of specialized pro-resolving lipid mediators and promotes resolution of airway inflammation

Koltsida, Ourania, Karamnov, Sergey, Pyrillou, Katerina, Vickery, Thad, Chairakaki, Aikaterini-Dimitra, Tamvakopoulos, Constantin, Sideras, Paschalis, Serhan, Charles N., Andreakos, Evangelos

Journal:

EMBO Molecular Medicine

Year:

2013

Language:

english

File:

PDF, 2.22 MB

english, 2013

32

Matrix metalloproteinase-2 is required for the switch to the angiogenic phenotype in a tumor model

Fang, J., Shing, Y., Wiederschain, D., Yan, L., Butterfield, C., Jackson, G., Harper, J., Tamvakopoulos, G., Moses, M. A.

Journal:

Proceedings of the National Academy of Sciences

Year:

2000

Language:

english

File:

PDF, 358 KB

english, 2000

33

Evaluation of a Stable Gonadotropin-Releasing Hormone Analog in Mice for the Treatment of Endocrine Disorders and Prostate Cancer

Katsila, T., Balafas, E., Liapakis, G., Limonta, P., Montagnani Marelli, M., Gkountelias, K., Tselios, T., Kostomitsopoulos, N., Matsoukas, J., Tamvakopoulos, C.

Journal:

Journal of Pharmacology and Experimental Therapeutics

Year:

2011

Language:

english

File:

PDF, 1.60 MB

english, 2011

34

Su1894 Identification of a Novel Function of Corticotropin Releasing Factor (CRH) in the Repair of Intestinal Epithelium in DSS Colitis

Giannogonas, Panagiotis, Apostolou, Athanasia P., Agrafiotou, Panagiota, Tamvakopoulos, Costantin, Pothoulakis, Charalabos, Karalis, Katia P.

Journal:

Gastroenterology

Year:

2015

Language:

english

File:

PDF, 615 KB

english, 2015

35

Perianal Ecchymosis as a Clinical Sign

Tamvakopoulos, Spiros K.

Journal:

Archives of Surgery

Year:

1969

Language:

english

File:

PDF, 359 KB

english, 1969

36

Granular Cell Tumours: A Rare Entity in the Musculoskeletal System

Rose, Barry, Tamvakopoulos, George S., Yeung, Eric, Pollock, Robin, Skinner, John, Briggs, Timothy, Cannon, Steven

Journal:

Year:

2009

Language:

english

File:

PDF, 1.49 MB

english, 2009

37

Perianal Hematoma — A Sign of Leakage after Rupture of Aortic Aneurysm

Tamvakopoulos, Spiros K., Corvese, William P., Vargas, Lester L.

Journal:

Boston Medical and Surgical Journal

Year:

1969

File:

PDF, 1018 KB

1969

38

Pyogenic Sacroiliitis After Delivery With Lower Segment Caesarean Section

Tamvakopoulos, George S., Ayekoloye, Charles, Elias, David A., Li, Patrick

Journal:

Journal of Pelvic Medicine and Surgery

Year:

2006

Language:

english

File:

PDF, 221 KB

english, 2006

39

A gemcitabine based peptide conjugate with improved metabolic properties, dual mode of action and efficacy in animal models

Karampelas, T., Skavatsou, E., Argyros, O., Tamvakopoulos, C.

Journal:

European Journal of Cancer

Year:

2016

Language:

english

File:

PDF, 70 KB

english, 2016

40

Gemcitabine Based Peptide Conjugate with Improved Metabolic Properties and Dual Mode of Efficacy

Karampelas, Theodoros, Skavatsou, Eleni, Argyros, Orestis, Fokas, Demosthenes, Tamvakopoulos, Constantin

Journal:

Molecular Pharmaceutics

Year:

2017

Language:

english

File:

PDF, 3.36 MB

english, 2017

41

Versatile quarto stimuli nanostructure based on Trojan Horse approach for cancer therapy: Synthesis, characterization, in vitro and in vivo studies

Efthimiadou, Eleni K., Fragogeorgi, Eirini, Palamaris, Lazaros, Karampelas, Theodoros, Lelovas, Pavlos, Loudos, George, Tamvakopoulos, Constantin, Kostomitsopoulos, Nikolaos, Kordas, George

Journal:

Materials Science and Engineering: C

Year:

2017

Language:

english

File:

PDF, 1.45 MB

english, 2017

42

Dexamethasone induces ω3-derived immunoresolvents driving resolution of allergic airway inflammation

Pyrillou, Katerina, Chairakaki, Aikaterini-Dimitra, Tamvakopoulos, Constantin, Andreakos, Evangelos

Journal:

Journal of Allergy and Clinical Immunology

Year:

2018

Language:

english

File:

PDF, 2.05 MB

english, 2018

43

DNA and Protein Metabolism After Liver Autotransplantation

Tamvakopoulos, S.K., Randall, H.T., VanLancker, J.

Journal:

European Surgical Research

Year:

1969

File:

PDF, 839 KB

1969

44

Development of bioactive gemcitabine-D-Lys6-GnRH prodrugs with linker-controllable drug release rate and biopharmaceutical profile

Sayyad, Nisar, Vrettos, Eirinaios I., Karampelas, Theodoros, Chatzigiannis, Christos M., Spyridaki, Katerina, Liapakis, George, Tamvakopoulos, Constantin, Tzakos, Andreas G.

Journal:

European Journal of Medicinal Chemistry

Year:

2019

Language:

english

File:

PDF, 1000 KB

english, 2019

45

Medium-Term Follow-Up Series Using a Modular Distal Fixation Prosthesis to Address Proximal Femoral Bone Deficiency in Revision Total Hip Arthroplasty. A 5- to 9-Year Follow-Up Study

Tamvakopoulos, G.S., Servant, C.T.J., Clark, G., Ivory, J.P.

Journal:

Hip International

Year:

2007

Language:

english

File:

PDF, 365 KB

english, 2007

46

Design, synthesis and biological evaluation of novel substituted purine isosters as EGFR kinase inhibitors, with promising pharmacokinetic profile and in vivo efficacy

Gavriil, Efthymios-Spyridon, Doukatas, Aris, Karampelas, Theodoros, Myrianthopoulos, Vassilios, Dimitrakis, Spyridon, Mikros, Emmanuel, Marakos, Panagiotis, Tamvakopoulos, Constantin, Pouli, Nicole

Journal:

European Journal of Medicinal Chemistry

Year:

2019

Language:

english

File:

PDF, 2.74 MB

english, 2019

47

Design, synthesis and biological evaluation of novel substituted purine isosters as EGFR kinase inhibitors, with promising pharmacokinetic profile and in vivo efficacy

Gavriil, Efthymios-Spyridon, Doukatas, Aris, Karampelas, Theodoros, Myrianthopoulos, Vassilios, Dimitrakis, Spyridon, Mikros, Emmanuel, Marakos, Panagiotis, Tamvakopoulos, Constantin, Pouli, Nicole

Journal:

European Journal of Medicinal Chemistry

Year:

2019

File:

PDF, 2.74 MB

2019

48

[BMJ Publishing Group Ltd Abstracts of the 25th Biennial Congress of the European Association for Cancer Research, Amsterdam, The Netherlands, 30 June â 3 July 2018 - ()] Poster Presentation - PO-444âEvaluation of novel nucleoside analogues for lung cancer treatment: an approach based on metronomic chemotherapy

Skavatsou, E, Karampelas, T, Tamvakopoulos, C

File:

PDF, 84 KB

49

Development of programmable gemcitabine-GnRH pro-drugs bearing linker controllable âclickâ oxime bond tethers and preclinical evaluation against prostate cancer

Vrettos, Eirinaios I., Karampelas, Theodoros, Sayyad, Nisar, Kougioumtzi, Anastasia, Syed, Nelofer, Crook, Timothy, Murphy, Carol, Tamvakopoulos, Constantin, Tzakos, Andreas G.

Journal:

European Journal of Medicinal Chemistry

Year:

2020

File:

PDF, 3.00 MB

2020

50

Managing NON-DIAGNOSTIC biopsies in musculoskeletal tumours in a specialist centre: Deciding on the algorithm

Tamvakopoulos, George S., Rose, Barry, Saifuddin, Asif, Skinner, John A., Pollock, Robin

Journal:

European Journal of Surgical Oncology (EJSO)

Year:

2020

File:

PDF, 830 KB

2020

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